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In an in vitro, 3D skin model with healthy tissues, DermCeutical - InflammagePRO™ was shown to upregulate genes that support skin moisture barrier maintenance while simultaneously downregulating inflammatory genes.
DermCeutical InflammagePRO™ supports improved keratin production and upregulates genes involved in the formation of outer skin protective barrier
DermCeutical InflammagePRO™ decreases several inflammatory markers,
including PTGS2, which have been shown to modulate skin aging
DermCeutical - InflammagePRO™ is a multifaceted polyphenol that not only supports the skin barrier and provides anti-inflammation benefits, but also targets the traditional mechanisms of aging through antioxidant activity elastase inhibition, and glycation inhibition for sustained skin health.
DermCeutical InflammagePRO™ is an antioxidant that scavenges free radicals formed by environmental aggressors like UV and pollution that exacerbate inflammaging.
DermCeutical InflammagePRO™ inhibits elastase activity, which has been shown to activate collagen breakdown and damage the extracellular matrix.
DermCeutical InflammagePRO™ inhibits glycation contributing to maintenance of skin’s extracellular matrix and preventing loss of skin elasticity and impaired cellular functions.
DermCeutical InflammagePRO™ shows a dose-dependent protective response in stressed skin cells that is 15x more potent (for IL-6) than niacinamide.
Protocol: Normal human epidermal keratinocytes were treated with an inflammatory cocktail and inflammatory markers subsequently measured by ELISA.
Results: DermCeutical InflammagePRO™ exhibits anti-inflammatory properties, decreasing IL-6 and TNF by 96% and 78%, respectively, when used at the topical equivalent of 0.45%. In both cases, inflammatory markers were nearly returned to the levels of un-stressed cells.
Placebo-controlled, double-blind study with 30 participants/group. Participants use the product twice daily and skin attributes are measured at T0, 4 weeks, and 8 weeks. Product used in DermCeutical InflammagePRO™ contained 0.45% DermCeutical - InflammagePRO™.
